One vs many

This old classic lets you pit up to five players, playing Hobbits, vs one, who would control the forces of Sauron. The Dark Lord player uses the Black Rider figures and special Sauron and Nazgul cards to haunt the poor Hobbits, who try their best to destroy the ring without getting captured or corrupted on the way. 

Note that the base game Lord of the Rings is a coop game and you will need to expansion to be able to play Sauron. With that said, the game and the expansion are out of print, but you might get lucky finding it on eBay or some thrift shop. Rest assured, however, if there will be a reprint of Reiner Knizia's masterpiece, we will tell you about it.

Remember what I said about detective games and that they dominate the one vs all genré?
Well, this is one of them, and dare I say the best one; Letters from Whitechapel, where one player gets to play Jack the Ripper, and the other policemen trying to catch him before he claims 5 victims.
The scene of it all is, of course, the Whitechapel district in London 1888, with its crowded and smelly alleys, shouting merchants, dirty children covered in rags who run through the crowd and beg for money, and prostitutes, -all laid out on a beautiful board. Jack moves through the city with hidden movements, and the rest are trying to find him an/or his lair before he can kill again.
This should be played at a very high pace, and if so, it's a very intense and unique gaming experience that every gamer should try out, but, obviously, the theme might not fit the younger crowd.

This awesome semi-coop deckbuilding game can also be played in a "one vs many" format, all you need is the base game and either of the Secret War expansions.
The game revolves around trying to defeat one of the iconic masterminds, like Dr. Doom, Magneto, or Loki, with a team of superheroes. Each hero and Mastermind have their own decks, of which you construct a "Hero deck" and a "Villain deck". The heroes will try to defeat the Masterminds henchmen and eventually the Mastermind itself before it can execute its evil scheme.
With the Secret War expansions, one player can play as the Mastermind and make life miserable for the other players. Marvel: Legendary can be expanded beyond oblivion as the game has about 20 expansions up to date. That itself is a testament to its greatness.

It is the 25th century. You are a member of an intergalactic expedition shipwrecked on a mysterious planet named Artemia. While waiting for the rescue ship, you begin to explore the planet but an alien entity picks up your scent and begins to hunt you. You are Not Alone! Will you survive the dangers of Artemia?
As you might have guessed, in this game one player is controlling an alien creature trying to assimilate the rest of the players by playing various cards. The rest of the players are also playing cards to do the direct opposite. not Alone is a thematic game, where bluffing, guessing, and managing your hand of cards will lead to the total assimilation of the humans, or their escape. This game does well with many players and plays quick. Recommended for beginners and veterans alike.

Imperial Assault invites you to play through a cinematic tale set in the Star Wars universe. One player commands the seemingly limitless armies of the Galactic Empire, threatening to extinguish the flame of the Rebellion forever. Up to four other players become heroes of the Rebel Alliance, engaging in covert operations to undermine the Empire’s schemes. Over the course of the campaign, both the Imperial player and the Rebel heroes gain new experience and skills, allowing characters to evolve as the story unfolds.
This game comes with very cool miniatures, and if you like that sort of thing you're in for a treat; there is a TON of expansion out there, and if you like Star Wars this one is a no-brainer. One of the most popular one vs many games out there, if not THE most popular.

In Pandemic, several virulent diseases have broken out simultaneously all over the world! The players are disease-fighting specialists whose mission is to treat disease hotspots while researching cures for each of four plagues before they get out of hand.
This is a fantastic cooperation game that requires the On the Brink expansion to transform it into a one vs many games where one player takes the role of a bio-terrorist set on annihilating the world's population with nasty viruses and bacterias. 
With a theme that goes with the mechanics in such a perfect fashion, this game is an absolute classic and a very popular family game. Make no mistake, the game works very well for gamers aswell.

This fresh game brings you another one vs many experience when one player takes the role as John McClane trying to thwart Hans Gruber's plans for the robbery of the century and save the hostages in the process. With asymmetric play, and cool callbacks to Die Hards's most memorable scenes, characters, and events, this game is a no-brainer if you are a fan of the film.

The game is played on the Nakatomi building board, and with the help of cards, tokens, and miniatures, you will change the outcome of the movie. Or not. This game was made for the one vs all dynamic in mind, and it really shines in that regard.

It is 1898. London has returned to peace for eight years following Count Dracula's thwarted plans, or so they thought...In Fury of Dracula, one player Dracula secretly traveling the European countries, turning humans into vampires with his gruesome bite, and laying deadly traps for those hunting him, and this is where the other players come in.

The hunters must find Dracula (who leaves a hidden trail as he travels through cities) by exploring cities and trying to find his trail. Then they must defeat him in combat to win. Dracula, in turn, must gain enough influence to win, largely by avoiding detection as long as possible, but also from defeating hunters in single combat. As time passes, vampires mature, advancing the influence track and with each week that passes, despair tokens are placed until the very powerful Fury of Dracula is triggered.